Table of Contents
- 1 Ligandrol LGD-4033 Review
- 2 What is Ligandrol?
- 3 How does Ligandrol work?
- 4 How Long Does It Take To “Kick In”?
- 5 How to buy Ligandrol?
- 6 What to expect when taking Ligandrol?
- 7 How much should I take?
- 8 How Long Does it Stay In Your System?
- 9 Side Effects
- 10 Who Should Use Ligandrol?
- 11 Summary
Ligandrol LGD-4033 Review
Ligandrol , one of the new, popular testosterone-boosting supplements on the market, is also known as LGD-4033, and it works as a selective androgen receptor modulator (SARM). Popular among bodybuilders as a healthy replacement for Dianabol, a powerful muscle-building oral steroid, Ligandrol has similar effects as testosterone and binds selectively to the receptor of androgen in your muscle and bone. It has the activity of a partial agonist on the prostate and was developed to treat conditions or diseases that are related to bone and muscle deterioration. One advantage Ligandrol has over testosterone is the contrast in activity that it has on the body outside of the bone and muscle.
Currently, it is used for legitimate medical uses as well as a performance-enhancing drug. Bodybuilders use it as an alternative to steroids without the side effects to increase athletic performance and muscle mass. This is a popular supplement with many professionals and athletes who are mindful of their body composition and muscle size such as bodybuilders, cross-fitters, models, weightlifters, strongmen and athletes.
Ligandrol has recently seen a lot of hype in the news from athletes who have used these supplements that are performance enhancing even though it is not a steroid. For example, Will Grier from the Florida Gators had Ligandrol in his body during a routine drug test.
Even though it was created for therapeutic use, it can be misused for image enhancement by athletes. As a result of this misuse, a counterfeit doping substance market has now been created, which has led to poor pharmaceutical quality and creating a health risk for consumers. You can order Ligandrol from the link below.
What is Ligandrol?
Categorized as an SARM, Ligandrol is popular with athletes and bodybuilders for cutting and bulking. Recommended dosages of 10mg per day show that the supplement can lead to 5 to 10 pounds of lean mass gains each month. In the athletic and bodybuilding worlds, it is also used as an alternative to steroids that is side effect free.
Although it is used for both cutting and bulking, it is more popular for bulking, and there are many stories of huge weight gains while taking it. Some weight gains have been so great that they have created suspicions, as in the recent case of Will Grier when Ligandrol found itself in the headlines after a few football players got in trouble for using it. Grier, Florida Gator’s quarterback, found himself suspended for using it when it was found in his body during a routine drug test.
It is not officially classified as a steroid, but it has been banned as a performance-enhancing drug, so Grier will have to serve a one-year suspension, plus he will also have to undergo an appeals process. It has continued to become more popular among athletes like bodybuilders, strongmen, power lifters, models and cross-fitters due to the bulking features it offers.
In comparison to other products, it is relatively strong, and it has an androgenic and anabolic ratio of approximately 10 to one. To give you some perspective, testosterone has a ratio of one to one. There are also some that claim that Ligandrol is 11 times stronger than Ostarine, its popular competitor.
Ligandrol is a non-steroidal selective androgen receptor modulator (SARM). But what does that mean? An androgen is either a synthetic or natural compound that regulates the maintenance and development in vertebrates of male characteristics when it binds to androgen receptors. And this is why you will see androgens used as steroid hormones.
If an androgen receptor modulator (SARM) is selective, then that means it is targeting in the body and it has a high attraction for bonding with androgen receptors. So, when a SAM is selective, you can take it by mouth since it will only bind to a specific target area. It will bind in your muscles to androgen receptors, helping to increase your muscle mass, which is a great feature for those who find themselves losing muscle mass for various reasons.
There are lots of reasons why you may lose muscle. When you get older, you can lose muscle strength and muscle mass due to sarcopenia, which also increases your risk for physical disability, falls, fractures and, as a result, a low quality of life with many substantial health and economic effects. It also helps to prevent muscle wasting, which can include the loss of skeletal muscle.
You may see this symptom in cancer-related illnesses that can begin early in cancer’s progression and can affect your quality of life as well as your ability to tolerate chemotherapy and ultimately to survive the illness.
When you take SARMs, you increase your muscle mass as well as improve physical function, and it gives individuals a new possible therapy for both muscle wasting and cancer cachexia. SARMs control similar anabolic pathways that classical steroidal androgens target, but within a dose range where the effects on your muscle mass and function are normal with no androgenic side effects on the skin, hair or prostate.
Other illnesses like muscular dystrophy, chronic obstructive lung disease, some types of cancer and end-stage renal disease, when combined with the loss of physical function and muscle mass, will add to the limitations on your mobility and increase your risk for disability. As a result, there is a demand for anabolic therapies that can fight the muscle loss and physical function along with lessening the effects of disability in those that are losing muscle due to illness or aging. Androgens are one of the most developed of the various anabolic therapies that are offered today.
It may also prevent cancer cachexia, which can occur in individuals that have kidney disease, sepsis, cancer, AIDS and burns, which have the features of muscle wasting, decreased appetite and weight loss. Almost 30% of cancer-related deaths are the result of cachexia that causes respiratory muscles to waste away, which can cause pneumonia.
Studies have also shown that anabolic agents like nandrolone for cachexia have resulted in lean body mass and bone density improvements, but there are still side effects like liver toxicity and masculinization in women. LGD-4033 is the perfect SARM to selectively increase muscle mass, since it does not have the growth effect on the prostate or the increase in hematocrit which makes androgen treatment a more beneficial option.
LGD-4033 may also help prevent osteoporosis by stopping bone loss and increasing the formation of bones. In addition to vitamin D and calcium supplements, the use of bisphosphonates can be used by women and men to increase bone density by stopping osteoclast activity. When women use hormone replacement therapy, it is menopausal symptoms that are commonly treated, but it is no longer recommended for long-term treatment because of its increased risk of breast and endometrial cancer, thromboembolism and gallbladder disease.
Also known to have a positive effect on BMD, androgens help to increase periosteal bone formation, and they are important in maintaining bone mass. This is evidenced by men who have undergone androgen deprivation therapy (ADT) due to decreases in BMD for a prolonged period. There are likely to be benefits to both men and women that use SARMs for osteoporosis, because they don’t have the side effects of virilization that are often seen with steroidal androgens.
It is well-known that it is possible to increase muscle strength and mass through administering testosterone, but the side effects of this therapy have raised concerns. As a result, there has been a new effort to develop SARMs with a new class of tissue-selective androgen receptor ligands that can control the targeted anabolic pathways that were previously used by classical steroidal androgens.
In the last 10 years, there has a been large effort among pharmaceutical companies to create nonsteroidal SARMs that will treat muscle loss and the functional limitations that are often associated with aging and acute and chronic illness.
There has been more research over the last 20 years on this class of SARMs, and it has found LGD-4033 receptors that bind androgen with high selectivity and affinity and selectivity, so it will attach in a strong and targeted approach that will create the same therapeutic benefits of testosterone, but have better tolerability, safety and patient acceptance.
How does Ligandrol work?
By typing androgen receptors selectively, LGD-4033 shows anabolic activity in the muscles and bones instead of having any harmful effects on the prostate and sebaceous glands that occur when using steroids. So far, clinical runs have shown that Ligandrol has the capabilities to provide the following benefits when the supplement is taken consistently:
• Strength levels are increased
• Improvement in lean muscle mass
• Body fat drops
• Contains healing properties
• Does not include bad side effects that are usually caused by anabolic steroids and prohormones
Working as a selective androgen receptor modulator (SARM), it has a high attraction to attach to the androgen receptors. The name selective comes from its ability to attach to androgen receptors in your muscles and nowhere else. This is a legitimate drug for medical use as well as being utilized as a performance-enhancing supplement. Originally, the drug was created to treat diseases like muscular dystrophy and other illnesses that are linked to it like cancer or old age. So far, there has been limited research published on the how effective these SARMs are, but they have discovered two positive effects of LGD-4033 on bone measurements and skeletal muscle when the disease was placed in animal models of the disease.
There has been one study that has been published on how it affected humans as well as results from a Phase I Clinical Trial in 2010. This trial was the first time a study has been done on humans using it. This trial assessed the tolerability and safety of the substances as well as how the drug behaves in the body. This study used a single escalating dose, as well as a double blind and a study in almost 50 healthy volunteers.
In 2013, after a thorough three-week study of over seventy healthy men, Basaria reviewed the tolerability and safety of it. This was done in the hopes to create a path of longer trials to study the effectiveness of Ligandrol on older people for which SARMs could be helpful. In the study, the participants were randomly given the placebo or a dosage of either 0.1, 0.3, or 1.0 mg daily over 21 days. During the study, the researchers watched for tolerability, safety and how the substance was working within the body. In addition, they reviewed the effect that ascending doses had on muscle strength, lean body mass, sex hormones and stair-climbing power.
Even though this was a well-thought-out study, it had a pretty small sample size, and it was not founded on concerns of effect sizes, only on the study’s primary goal of established tolerability and safety. As a result, longer studies are needed to really decide on how effective it is on muscle strength and mass as well as establish its tolerability and safety.
So far, research by Basiria does show that it does not promote fat loss or increase testosterone. However, there is research by Basiria that shows there is an increase in muscle growth. This growth in lean body mass is related to the dose, so as the LGD dose was increased, the research showed that the effect on muscle mass also increased.
It is still not understood how androgens increase muscle mass, but it is thought that along with the increase in muscle mass that the individual would also have an increase in muscle strength. The research has shown SARMs to improve physical function as well as increase muscle mass in both diseased and healthy people, and it could possibly be used as a new therapy for diseases that cause muscle loss like cancer. There is also not enough research to show the increase in strength that is measured by stair climbing power and speed to be significant. Larger sample sizes and longer studies can help to demonstrate its effectiveness.
Its effects on increasing lean muscle mass and reducing body fat are well-known from studies and experiments, but Ligandrol can also improve strength for better training performance, recovery, and overall health. Many athletes and bodybuilders use LGD-4033 to help them improve their performance and strength and use it in the following ways:
With a suggested dosage of five to 10 mg a day for eight weeks with a protein-rich diet that is also needed, as well as higher caloric intake, you can expect to take on up to 10 pounds or more.
When you use LGD-4033 with a SARMS triple pack, it becomes more effective in adding more to your size while still cutting fat. There is a suggested dosage of 3 to 5 mg a day for eight weeks.
It is also best used for recomping, as many reviewers have found that they noticed a boost in their lean body mass and fat loss. When you use it together with other SARMS like Cardarine, you will get a better and strong recomp. There is a suggested dosage between 5 and 8 mg per day for eight weeks.
How Long Does It Take To “Kick In”?
Individuals who take it will see an instant result on hormones at the time that the substance is taken, and research has shown gains within the 21-day study in lean muscle mass. This is an incredibly short amount of time to see an effect from this type of substance.
How to buy Ligandrol?
Unless you are playing collegiate or professional sports, it is not currently banned or illegal and is available in several online stores such as ProvenPeptides.com that sells Ligandrol for around $59, which gets you 1oz . Taken orally, it is easy to take with no needles required. There are also some lower-quality supplement manufacturers that sell it in capsule form, but these capsules have extremely weak concentrations when compared to the liquid form, which is your best option. It is also pretty cheap in comparison to other SARMs.
What to expect when taking Ligandrol?
You should expect gains of 1 to 1 1/2 pounds per week when you start taking LGD. You will notice these gains happen when you eat a little more than the calories that are needed to maintain a high protein diet. Some people have even reported that their gains are like being on steroids, which leads to a controversy with it causing these weight gains as a simple effect of glycogen supercondensation, which means it has the steroid-like properties that tell your body to store more water and carbs than normal. If you stop taking LGD and cycle off, you will lose some of the weight that you have gained, which could simply be because your muscle is dropping the glycogen.
How much should I take?
The most common dosage of Ligandrol is between 5 and 10 mg per day. You can increase the dosage by 1 or 2 mg after three to four weeks, and you want to cycle off Ligandrol every six to 12 weeks.
How Long Does it Stay In Your System?
With a prolonged elimination half-life, it takes one half of the dose to leave your system in 24–36 hours. So, every 24-36 hours, the LGD level in your body drops by half, so the next day your LGD level will drop by half again, etc. when you stop using it, your hormone levels will return to their baseline by the 56th day.
There have been no major side effects that have been reported. However, it can suppress your testosterone level significantly while also lowering and suppressing your sex hormone binding globulin (SHBG) levels. But, after you take it for very short time, only one to three weeks, you will notice your testosterone levels go back to normal, which happens because it does not affect LH or FSH.
With no reported estrogenic system changes, there are some individuals who preferred to take an aromatase inhibitor anyway, plus it is recommended to have a short Post Cycle Therapy (PCT) treatment, but it’s not required, as it doesn’t cause that many problems with your libido or cause any other side effects. Plus, it is not reported to have any effect on liver toxicity, so you do not have to worry about long-term damage to your body’s organs.
Who Should Use Ligandrol?
If you play professional or collegiate sports, this is definitely not a supplement you should be using. Otherwise, it is a legal steroid alternative that does not have the dangerous side effects but works in the same way. Basiria showed that it is well tolerated and safe in its Phase I Trial at all doses that were administered at either 0.1, 0.3 or 1.0 mg. Any of the adverse effects were similar in frequency between any dose group and the placebo like a headache, dry mouth and pain related to muscle biopsy.
Since one of its most useful characteristics is its half-life, the prolonged elimination of LGD means it can be given less frequently during a dosing regimen and that it has a strong relationship between the concentration of blood plasma and the dose.
Over the last 10 years, there has been an emergence of several non-steroidal SARMs from quite a few pharmaceutical companies that are acting as the latest new group of function-promoting therapies that heal the low muscle mass. The effectiveness of it is very encouraging, as it has been shown to be safe and increase lean body mass in a short amount of time. Future research needs to be done to confirm its effectiveness and safety.